Pulsed Xenon Irradiation Device

What is a Pulsed Xenon Irradiation Device?

A sterilization method using "light" as an alternative to sterilization methods using heat.

Because sterilization by "light" involves instantaneous emission, it is more effective than sterilization by heating.

1. Contributes to reducing electricity costs
2. Contributes to CO₂ reduction
3. The object is less likely to deform or deteriorate.
4. In-line sterilization is now possible, improving productivity.

Furthermore, by employing a xenon lamp with high germicidal capabilities,

1. Because it uses mercury-free lamps, it is environmentally friendly and safe.
2. Achieved a level of high-level sterilization (3-6D value).

An example of an object

• Infusion soft bag
• Injection syringe
• Vial
• Ampoule
• Plastic bottle caps
• Dessert container
• Bread
• Rice cake

For more details on its use in food processing and packaging.

Case studies

• Nissin Pharmaceutical Co., Ltd.

  

  • Object: Physiological saline (20 ml plastic ampoule)
  • Method of use: Final sterilization

• Otsuka Pharmaceutical Factory, Inc.

  

  • Target materials: Physiological saline solution and drug solution (20 ml plastic ampoule)
  • Method of use: Sterilization

• Toa Pharmaceutical Co., Ltd.

  

  • Object: Chemical solution (150ml plastic bottle)
  • Method of use: Final sterilization

• Industrial Research Institute of Niigata Prefecture Applied Materials Technical Support Center

  

  • Target material: Nonwoven fabric for masks, etc.
  • Usage: Performance testing

Examples of sterilization tests using pulsed light irradiation

Test conditions (2000J experimental machine)

lamp

Pulsed xenon lamps (2 lights) for 2000J

Irradiation distance

75mm from the lamp center to the center of the bottle (from both sides)

Charging energy

1000J, 1500J, 2000J

Bacteria used

Black koji mold: Aspergillus niger var. awamori (JCM2261)

sample

20ml physiological saline (0.9%) PE bottle [Provided by Nisshin Pharmaceutical Co., Ltd.] *See photo in the bottom right

Method for measuring bacterial count

PE bottles injected with Aspergillus oryzae spores were pulsed at a fixed distance, then diluted to a fixed concentration, spread on PDA culture medium, and the bacterial count was measured.

Test Result

Charging energy	Number of pulses required for 6D value of 20mℓ PE bottle
1000J	3 pulses
1500J	2 pulses
2000J	1 pulse

Illuminance Monitoring System

In pharmaceutical-related factories, it is crucial to perform validation efficiently and accurately.

Details of the Illuminance Monitoring System